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On the other hand, the activation of STAT3 induced the expression of IGF-1R [51] indicating that the cytokine-mediated JAK/STAT3 pathway was able to sensitize insulin/IGF-1 signaling

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Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

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Consistently, the ACSL4 inhibitor rosiglitazone also had kidney protective effects against IRI-induced AKI by reducing the infiltration of immune cells and ferroptotic cell death [48, 151]

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